Monday, August 26, 2013

Long-Term Fda beloved designate Drugs for Weight Loss

Weight loss medications are generally either prescription or non-prescription based. prescription drugs, also referred to as ethical drugs are medications which have been stylish by the Fda and which can only be procured through the approval of a physician.

Also, the separate available Fda stylish prescription weight loss drugs can be classified into two separate groups based on their recommended duration of use - which is either short- or long-term. This description will be focusing on the long-term group of Fda stylish prescription weight loss drugs.

However, it is leading to understand that prescription weight loss drugs in general, are only stylish to individuals who are determined to be either overweight (having a Bmi that is between 27 and 30 and who have obesity-related health conditions) or obese (with a Bmi over 30 and who also have obesity-related health conditions). Conditions such as heart disease, high blood pressure, high blood cholesterol, and type Ii diabetes are some of the obesity-related health conditions commonly considered.

While the short-term prescription weight loss drugs are all appetite suppressing medications, the long-term Fda stylish prescription weight loss drugs are however of two separate types based on their generic names and functions.

Sibutramine
Sibutramine is positively an appetite suppressant and was stylish by the Fda in 1997 to be used for up to two years in the treatment of obesity. It is sold under the brand name of Meridia in the United States and as Reductil in other countries.

Sibutramine works by inhibiting the reuptake of the catecholamine - norepinephrine, dopamine, and serotonin. While norepinephrine and dopamine (a precursor of epinephrine, aka adrenaline) increase blood pressure and the rate and depth of breathing, serotonin on the other hand carries signals of delight and create a relaxed mood.

The inhibition of the reuptake of these neurotransmitters by Sibutramine allows them to remain for longer periods in the synapses - the gaps between nerve endings - consequently prolonging their ability to act as transmitters of chemical signals. This leads to increased levels of the circulating amounts of these neurotransmitters in the body which consequently makes you feel more energetic and satiated for longer periods of time even with less food intake.

Additionally, Sibutramine inhibits the functions of the neurotransmitter neuropeptide Y which is believed to cause the body to eat, cut physical operation levels and increase fat storage. Sibutramine has been demonstrated to help about 85% of obese patients lose colse to 5% of their body weight while assisting 57% lose about 10%.

While the protection and efficacy of using Sibutramine for more than two years has not been established, some of the immediate side effects consist of increased blood pressure, dry mouth, headache, constipation, and insomnia. Furthermore, population with a history of uncontrolled high blood pressure, congestive heart failure, heart disease, or stroke are advised not to use Sibutramine.

Orlistat
The first Fda-approved non-appetite suppressing rescription weight loss medication, Orlistat, was stylish on the 26th of April, 1999. Orlistat, also known as tetrahydrolipstatin (Thl), is classified under the drug class known as lipase inhibitors and is marketed under the brand name Xenical.

Orlistat prevents the digestion and absorption of dietary fats into the bloodstream by inhibiting the pancreatic enzyme, lipase. Orlistat reduces the production of pancreatic lipase (which is the enzyme that facilitates the break down of fats within the intestine) thereby stopping consumed dietary fat from being hydrolyzed into free fatty acids which can be absorbed into the bloodstream. The undigested fat is subsequently excreted within feces.

It has been found that lipase inhibitors can help cut the whole of absorbed dietary fat by as much as 30%. When combined with a reduced calorie but nutritionally balanced diet, Orlistat helped adults lose about 12.4 to 13.4 pounds on an median within six months.

Most of the known side effects of using Orlistat have been reported within the first year of usage with most of the severity and occurrences reducing over time. However, most of these side effects which consist of diarrhea, bloating, flatulence, and also loose, fatty, or oily stool tend to be acute especially following the consumption of fatty foods.

Some other side effects consist of abdominal, rectal, or chest pain; nasal congestion and difficult breathing; fever and headaches; and also runny nose, sneezing and sore throat. Furthermore, Orlistat is known to inhibit the absorption of fat-soluble vitamins especially A, D, E, and K as well as beta carotenes. Users are therefore advised to take multivitamin supplements daily. The long-term corollary of using Orlistat are yet unknown.

However, if you are finding for a weight loss medication that offers you much more weight loss benefits without all these side effects, then you might want to consider using Phen375.

Phen375, also known as Phentemine375, is a new clinically proven and efficient pharmaceutical-grade appetite suppressant and fat burner. Phen375 is man-made in Fda registered pharmaceutical labs in California and made from high ability active ingredients such as Dimethylpentalyne, Trimethylxanthine, Dehydroepiandrosterone (Dhea), and L-carnitine.

The aggregate of these compounds in Phen375 virtually makes it the Most fine non-prescription weight loss supplement available today.


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